解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Clusterin (apolipoprotein J) is a highly conserved, multifunctional, vertebrate glycoprotein. Several isoforms of clusterin have been described including the predominant secreted isoform (sCLU) and several nuclear isoforms (nCLU) associated with cell death. sCLU has been shown to bind a variety of partly unfolded, str...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20374
更新日期:2005-02-15 00:00:00
abstract::It is known that expression of glial fibrillary acidic protein (GFAP) as an astrocyte-specific marker can be regulated by levels of circulating gonadal steroids during postnatal development. In addition, astrocytes play an important role in the physiology of the hippocampus, a brain region considered sexually dimorphi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20372
更新日期:2005-02-15 00:00:00
abstract::Increased serum level of homocysteine, a sulfur-containing amino acid, is considered a risk factor in vascular disorders and in dementias. The effect of homocysteine and metabolically related compounds on brain production of kynurenic acid (KYNA), an endogenous antagonist of glutamate ionotropic receptors, was studied...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20359
更新日期:2005-02-01 00:00:00
abstract::Fibroblast growth factors (FGFs) are important regulators of retinal development and survival. We examined the expression and distribution of FGF9 and its preferred receptors FGFR2IIIc and FGFR3IIIc in this tissue. FGF9 transcripts in whole rat retina were detected by RT-PCR but were not present in purified cultured M...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20363
更新日期:2005-02-01 00:00:00
abstract::Monocarboxylate transporters (MCTs) are involved in the uptake and release of lactate, pyruvate, and ketone bodies. Studies of their distribution at both the mRNA and protein levels have highlighted the specific expression of MCT1, MCT2, and more recently MCT4 in the central nervous system. MCT1 was found strongly exp...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20307
更新日期:2005-01-01 00:00:00
abstract::Peroxides are generated continuously in cells that consume oxygen. Among the different peroxides, hydrogen peroxide is the molecule that is formed in highest quantities. In addition, organic hydroperoxides are synthesized as products of cellular metabolism. Generation and disposal of peroxides is a very important proc...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.20280
更新日期:2005-01-01 00:00:00
abstract::The 14-3-3 proteins exist predominantly in the brain and may play regulatory roles in cellular processes of growth, differentiation, survival, and apoptosis. The biological functions, however, of the various 14-3-3 isoforms (beta, epsilon, eta, gamma, and zeta) in the brain remain unclear. We have reported previously ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20323
更新日期:2005-01-01 00:00:00
abstract::The Brn-3a transcription factor is critical for survival and differentiation of sensory neurons derived from neural crest cells (NCC). Interaction of Brn-3a with p53 results in differential effects on target gene expression, which profoundly affects fate of neuronal cells. Here we demonstrate colocalization of p53 in ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20299
更新日期:2004-12-15 00:00:00
abstract::Dopaminergic afferents from the mesencephalic areas, such as ventral tegmental area (VTA), synapse with the gamma-aminobutyric acid (GABA)-ergic interneurons in the prefrontal cortex (PFC). Pharmacological and electrophysiological data show that the reinforcement, the dependence-producing properties, as well as the ps...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20329
更新日期:2004-12-15 00:00:00
abstract::Highly malignant neuroblastoma tumors generally have defects in differentiation and apoptotic pathways. For a better understanding of these events, we use a murine neuroblastoma cell line (NBP2) that terminally differentiates into mature neurons in response to elevated levels of cAMP. Because one of the main downstrea...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20304
更新日期:2004-11-15 00:00:00
abstract::Fetal low brain oxygenation may be an outcome of maternal complications during pregnancy and is associated with increased risk of cerebral palsy and periventricular leukomalacia in newborns. One treatment used for prevention of fetal brain damage is maternal treatment with MgSO(4). Although this treatment is indicated...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20269
更新日期:2004-11-01 00:00:00
abstract::Differentiated human NT2-N neurons were shown to express CCR5 and CXCR4 chemokine receptor mRNA and protein, and to be responsive to the chemokines CCL5 and CXCL12. Using cDNA microarray technology, CCL5 was found to induce a distinct transcriptional program, with reproducible induction of 46 and 9 genes after 2 and 8...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20250
更新日期:2004-11-01 00:00:00
abstract::The neonatal lesion with 6-hydroxydopamine (6-OHDA) in rodents induces juvenile hyperactivity and paradoxical hypolocomotor response to psychostimulants, in striking contrast to what is observed when similar lesions are carried out in adults. The early disruption of central dopaminergic pathways is followed by increas...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20245
更新日期:2004-10-15 00:00:00
abstract::We investigated whether certain hydrophobic dipeptides, Leu-Ile, Leu-Pro, and Pro-Ile, which partially resemble the site on FK506 that binds to immunophilin, could stimulate glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) synthesis in cultured neurons and found only Leu-...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20258
更新日期:2004-10-15 00:00:00
abstract::Catecholamine-producing cell types are generated from specified neuronal lineages during vertebrate development. The catecholaminergic phenotype is also expressed transiently in some cell types in non-catecholaminergic tissues, including the sensory ganglia, enteric ganglia, and ventral portions of the neural tube dur...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20229
更新日期:2004-10-01 00:00:00
abstract::The companion study showed that acoustic overstimulation of adult chinchillas, with a noise level sufficient to damage the cochlea, led to cytological changes and degeneration of synaptic endings in the cochlear nucleus within 1-16 weeks. In the present study, the same stimulus was used to study the long-term effects ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20212
更新日期:2004-09-15 00:00:00
abstract::Microarray analyses demonstrated that a variety of genes was affected by treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor (PEDF). The genes for neurotrophins, glial cell-derived neurotrophic factor (GDNF), and their receptors were regulated differentially in i...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20196
更新日期:2004-09-01 00:00:00
abstract::Ionotropic N-methyl-D-aspartate (NMDA) receptor agonists, L-aspartic acid (L-Asp) and NMDA, have been shown to inhibit histamine-stimulated acid secretion, but their effect on gastric mucosal blood flow (GMBF) is largely unknown. The aim of this study was to investigate whether L-Asp and NMDA inhibit histamine-stimula...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20202
更新日期:2004-09-01 00:00:00
abstract::The twitcher mouse is well known as a naturally occurring authentic mouse model of human globoid cell leukodystrophy (GLD; Krabbe disease) due to genetic deficiency of lysosomal galactosylceramidase. The twitcher mice used most commonly are on the C57BL/6J background. We generated twitcher mice that were on the mixed ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20190
更新日期:2004-08-15 00:00:00
abstract::The metabolism of glutamate, the most likely neurotransmitter of vestibular ganglion cells, includes synthesis from glutamine by the enzyme glutaminase. We used microdissection combined with a fluorometric assay to measure glutaminase activity in the vestibular nerve root and nuclei of rats with unilateral vestibular ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20179
更新日期:2004-08-15 00:00:00
abstract::Astroglial participation in the regional differences of vulnerability to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-induced neurodegeneration was investigated in the rat hippocampus and medial septum using L-alpha-aminoadipate (alpha-AA) as a specific astroglial toxin. alpha-AA was microinjected i...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20177
更新日期:2004-08-01 00:00:00
abstract::We present here a fast protocol that could be used to obtain highly purified cultures of maximal proliferating adult rat Schwann cells. These adult rat Schwann cells can be transfected in a nonbiological way using the physical transfection method of electroporation. Schwann cells are decisive in recovery of peripheral...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20166
更新日期:2004-08-01 00:00:00
abstract::The ligand-activated transcription factor peroxisome proliferator-activated receptor beta (PPARbeta) is present in the brain and is implicated in the regulation of genes with potential roles in neurotoxicity. We sought to examine the role of PPARbeta in neuronal cell death by using the PPARbeta ligand GW0742. Primary ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20153
更新日期:2004-07-15 00:00:00
abstract::Recent data indicate that molecular mimicry may play a role in the pathogenesis of human-T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), an immune-mediated disease of the central nervous system (CNS). Specifically, HAM/TSP patients developed antibodies that cross-reac...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20137
更新日期:2004-07-01 00:00:00
abstract::The most visible and, until very recently, the only hypothesis regarding the involvement of microglial cells in Alzheimer's disease (AD) pathogenesis is centered around the notion that activated microglia are neurotoxin-producing immune effector cells actively involved in causing the neurodegeneration that is the caus...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.20093
更新日期:2004-07-01 00:00:00
abstract::The birth of cells with neurogenic potential in the adult brain is assessed commonly by detection of exogenous S phase markers, such as bromodeoxyuridine (BrdU). Analysis of other phases of the cell cycle, however, can provide insight into how external factors, such as opiates, influence the cycling of newly born cell...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20090
更新日期:2004-06-15 00:00:00
abstract::We studied the effects of electrical stimulation of the inferior alveolar nerve (IAN) on cardiovascular responses in cats. There was statistical correlation between cardiovascular response and prestimulus mean arterial blood pressure (MABP) and heart rate (HR). A trigeminal depressor response (TDR) was induced when th...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20131
更新日期:2004-06-15 00:00:00
abstract::HAND2 (also known as dHAND) is a basic helix-loop-helix (bHLH) transcription factor essential for development of the heart, limbs, and neural crest-derived lineages. HAND2 expression is observed in a number of tissues derived from the neural crest, including components of the peripheral nervous system, where it has be...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20105
更新日期:2004-06-01 00:00:00
abstract::The large, medium-sized, and small neurons of the dorsal root ganglion (DRG) have different functions in the processing of various senses. Hyperpolarization-activated, cyclic nucleotide-gated channels (HCN) contribute greatly to neuronal excitability. In the present study, which used whole-cell patch clamp techniques ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20109
更新日期:2004-06-01 00:00:00
abstract::Increase of intracellular [Ca(2+)] evoked by action potentials in a cell can induce long-term synaptic plasticity even without concomitant presynaptic stimulation. We used optical recording of the fluorescence of a Ca(2+)-indicator Oregon Green to investigate whether differences in results obtained with modifications ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20104
更新日期:2004-05-15 00:00:00
abstract::Gamma-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter of CNS, has been consistently implicated in the pathophysiology of schizophrenia. GABA is synthesized from glutamate by the enzyme glutamic acid decarboxylase (GAD). Two isoforms of GAD have been identified and have been named GAD65 and GAD67 ba...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20122
更新日期:2004-05-15 00:00:00
abstract::In the striatum, dopamine (DA) exerts a major modulatory influence on voltage- and ligand-gated currents. Previously we have shown that DA modulates glutamatergic neurotransmission and that the direction of this modulation depends on, among other factors, the glutamate and DA receptor subtypes activated. These effects...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20079
更新日期:2004-05-01 00:00:00
abstract::The precise function of APP (Alzheimer's amyloid precursor protein) remains to be fully elucidated, but various lines of evidence suggest that it may be involved in cell adhesion processes. Because APP is a transmembrane glycoprotein, variations in its expression level may have direct bearing on its putative role in c...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20091
更新日期:2004-05-01 00:00:00
abstract::Mitotic activity persists in various regions of the adult mammal CNS. While evidences of neurogenesis appeared, many studies focused on the features of the adult stem cells from germinative areas such as the subventricular zone of the lateral ventricles, the dentate gyrus of the hippocampus, the cortex, the fourth ven...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.20040
更新日期:2004-04-15 00:00:00
abstract::Progressive "dying back" neurodegenerative diseases are debilitating due to loss of connectivity after nerve terminal and axonal withdrawal, which impairs peripheral nerve function and leads ultimately to neuronal cell death. The mutant mouse (Wallerian degeneration slow; Wld(s)) provides an accessible model system to...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20016
更新日期:2004-04-01 00:00:00
abstract::In culture, cerebellar granule neurons die of apoptosis in serum-free media containing a physiologic level of K(+) but survive in a depolarizing concentration of K(+) or when insulin-like growth factor 1 (IGF-1) is added. Both Akt/PKB activation and caspase-3 inhibition were implicated as the underlying neuroprotectiv...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20024
更新日期:2004-03-15 00:00:00
abstract::The first synapse in the olfactory pathway mediates a significant transfer of information given the restricted association of specific olfactory receptor neurons with specific glomeruli in the olfactory bulb. To understand better how this connection is made and what the functional capacities of the participating cells...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20007
更新日期:2004-03-01 00:00:00
abstract::Metabotropic glutamate receptors (mGluRs) and calcium receptors (CaR) are closely related G protein-coupled receptors (GPCRs). The similar structural and functional properties of mGluRs and CaRs include conserved amino acid residues involved in glutamate binding in mGluRs and Ca2+ binding in the CaR. Furthermore, rece...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10853
更新日期:2004-02-15 00:00:00
abstract::A link between aluminum (Al) exposure and age-related neurological disorders has long been proposed. Although the exact mechanism by which the metal may influence disease processes is unknown, there is evidence that exposure to Al causes an increase in both oxidative stress and inflammatory events. These processes hav...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10877
更新日期:2004-02-15 00:00:00
abstract::We have determined the localization of Cav1.2 (L-Type) Ca2+ channels in the cells and nerve fibers in molars of normal or injured rats. We observed high levels of immunostaining of L-type Ca2+ channels in odontoblast cell bodies and their processes, in fibroblast cell bodies and in Schwann cells. Many Cav1.2-containin...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10863
更新日期:2004-02-01 00:00:00